40 Clinical Studies on New Products clinically proven safe to use without gum protection
*Effects of tooth whitening and orange juice on surface properties Yan-Fang Ren *, Azadeh Amin, Hans Malmstrom University of Rochester Eastman Dental Centre, 625 Elmwood Avenue, Rochester, 14620, NY, United States; Accepted 26 January 2009
Their findings that the Beyond 6% HP whitening gel was safer than Orange juice* on teeth surface properties was published in Journal of Dentistry.
Safer than Orange Juice
Note: This report by Eastman Dental Centre also contains reference to 45 other clinical studies

In addition:
DENTIST PRESCRIBED teeth whitening using trays without any protective barrier Effectiveness of Dentist-Prescribed, Home-Applied Tooth Whitening, Published in the Journal of Contemporary Dental Practice. A Meta-analysis by Researchers: Richard Niederman DMD, MS; Maggie C Tantraphol; Patricia Slinin.DMD; Catherine Hayes, DMD, DMSc; Suzy Conway MLS
Note: This report cites reference to 32 other clinical studies

1. Haywood VB, Heymann HO. Nightguard vital bleaching. Quintessence Int 1989;20(3): 173-6.
2. Haywood VB, Leonard RH, Nelson CF, Brunson WD. Effectiveness, side effects, and long-term status of nightguard vital bleaching. J Am Dent Assoc 1994;125: 1219-1226.
3. Gegauff AG, Rosenstiel SF, Langhout KJ, Johnston WM. Evaluating tooth color change from carbamide peroxide gel. J Am Dent Assoc 1993;134: 65-72.
4. Robertson WD, Melfi RC. Pulpal response to vital bleaching procedures. J Endod 1980;6: 645-9.
5. Cohen SC. Human pulpal response to bleaching procedures on vital teeth. J Endod 1979;5: 134-8.
6. Council on Dental Therapeutics. Guidelines for the acceptance of peroxide-containing oral hygiene products. J Am Dent Assoc 1994;125: 1140-1142.
7. Levine R, Shaneman R. An evidence-based treatment approach: Translating clinical outcomes to patient value. Int J Periodontics Restorative Dent 1998;3: 327-38.
8. Sackett DL, Richardson WS, Rosenberg W, Haynes RB. Evidence-based medicine. How to practice and teach EBM. New York: Churchill Libingsone, 1997.
9. Crim GA. Post-operative bleaching: effect on microleakage. Am J Dent 1992;5(2): 109-12.
10. Hansen-Bayless J, Davis R. Sealing ability of two intermediate restorative materials in bleached teeth. Am J Dent 1992;5(3): 141-4.
11. Miles PG, Pontier JP, Bahiraei D, Close J. The effect of carbamide peroxide bleach on the tensile bond strength of ceramic brackets: an in vitro study. Am J Orthod Dentofacial Orthop. 1994;106(4): 371-5.
12. Heymann HO, Swift EJ Jr., Bayne SC, May KN Jr., Wilder AD Jr., Mann GB, Peterson CA. Clinical evaluation of two carbamide peroxide tooth-whitening agents. Compend Contin Educ Dent 1998;19(4): 359-62, 364-6, 369.
13. Kowitz GM, Nathoo SA, Wong R. Comparative clinical evaluation of two professional tooth-whitening products. Compendium 1994; Suppl 17: S635-9.
14. Nathoo SA, Chmielewski MB, Rustogi KN. Clinical evaluation of Colgate Platinum Professional Toothwhitening System and Rembrandt Lighten Bleaching Gel. Compendium 1994;
Suppl 17: S640-5.
15. Schulte JR, Morrissette DB, Gasior EJ, Czajewski MV. Clinical changes in the gingiva as a result of at-home bleaching. Compendium1993;14(11) 1362, 1364-6.
16. Schulte JR, Morrissette DB, Gsior EJ, Czajewski MV. The effects of bleaching application time on the dental pulp. J Am Dent Assoc 1994;125(10): 1330-5.
17. Matis BA, et.al. In vivo degradation of bleaching gel used in whitening teeth. J Am Dent Assoc 1999 Feb;130(2): 227-35.
18. Fischman SL, Truelove RB, Hart R, Cancro LP. The laboratory and clinical safety evaluation of a dentrifice containing hydrogen peroxide and baking soda. J Clin Dent. 1992;3(4): 104-10.
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20. Kugel G, Perry RD, Hoang E, Scherer W. Effective tooth bleaching in 5 days: using a combined inoffice and at-home bleaching system. Compend Contin Educ Dent 1997; 18(4): 378, 380-3.
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22. Matis BA, Cochran MA, Eckert G, Caroson TJ. The efficacy and safety of a 10% carbamide peroxide bleaching gel. Quintessence Int 1998;29(9): 555-63.
23. Rosenstiel SF, Gegauff AG, Johnston WM. Randomized clinical trial of the efficacy and safety of a home bleaching procedure. Quintessence Int 1996;27(6): 413-24.
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Dentist-supervised home bleaching with ten percent carbamide peroxide gel: a six-month study. J Esthet Dent 1996;8(4): 177-82.
25. Kowitz Gm, Nathoo SA, Rustogi KN, Chmielewski MB, Liang LJ, Wong R. Clinical comparison of Colgate Platinum Toothwhitening System and Rembrandt Gel Plus. Compendium 1994; Suppl 17: S646-51.
26. Reinhardt JW, Elvins SE, Swift EJ Jr., Denehy GE. A clinical study of nightguard vital bleaching. Quintessence Int 1993; 24(6): 379-84. 14 The Journal of Contemporary Dental Practice, Volume 1, No. 4, Fall Issue, 2000
27. Howard WR. Patient-applied tooth whiteners. J Am Dent Assoc 1992;123(2): 57-60.
28. Curtis JW, Dickinson GL, Downey MC, Russell CM, Haywood VB, Myers ML, Johnson MH. Assessing the effects of 10 percent carbamide peroxide on oral soft tissues. J Am Dent Assoc 1995;127(8): 1218-23.
29. Egger M, Smith GD. Meta-Analysis: Potentials and promise. BMJ 1997:315: 1371-4.
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Other Clinical studies on BARRIER FREE products:
(1) Clinical Study Protocol Number: EBRIGHT-2007-01) Study prepared by YANFANG REN, D.D.S., Ph.D., MPH Associate Professor and Associate Chair Division of General Dentistry University of Rochester Eastman Dental Centre using a 6%HP gel painted onto teeth and using a light Accelerator in a barrier free environment
(2) 12-Month Post-Treatment Safety and Efficacy of 10% Hydrogen Peroxide Strips R.W. GERLACH1, M.L. BARKER1, L.A. BOWMAN1, L. BENZ2,
K. KARPINIA2, and I. MAGNUSSON2 1 P&G, Mason, OH, USA 2 University of Florida, Gainesville, USA
(3) Clinical Trial Comparing Daytime and Overnight Tooth Whitening Systems (10% hydrogen peroxide) K. KARPINIA1, I. MAGNUSSON1, M.L. BARKER2, and
R.W. GERLACH2 1 University of Florida, Gainesville, USA 2 P&G, Mason, OH, USA
(4) Long-term Evaluation of Efficacy of a Hydrogen Peroxide Whitening Strip (10% hydrogen peroxide whitening strip) X. WANG, Peking University, School of Stomatology, Beijing,
China
(5) 10% Hydrogen Peroxide Whitening Strips: Evidence from 8 Clinical Trials M.L. Barker, R.A. Baker, H. Shahidi*, P.A. Sagel, R.W. Gerlach P&G, Mason, OH, USA
(6) Clinical Trial Evaluating Two Peroxide Whitening Strips Used by Teenagers K.J. DONLY1, A. JAMISON1, and R.W. GERLACH2 1 University of Texas – San Antonio / Health Science Ctr, USA 2 P&G, Mason, OH, USA
(7) Surface Wettability of Oral Surfaces During Vital Tooth Bleaching H.J. BUSSCHER1, D. WHITE2, M.J. GIBCUS1, and H.C. VAN DER MEI1 1 University of Groningen, Thesinge, Netherlands 2 P&G, Mason, OH, USA
(8) Professional Vital Bleaching Using a Thin and Concentrated Peroxide Gel on Whitening Strips:14% HP. An Integrated Clinical Summary Gerlach RW, Barker ML. Professional Vital Bleaching Using a Thin and Concentrated Peroxide Gel on Whitening Strips: An Integrated Clinical Summary. J Contemp Dent Pract. 2004 February;(5)1:001-017. Published The Journal of Contemporary Dental Practice, Volume 5, No. 1, February 15, 2004